Biomarker Scientific Leader Oncology - PIERRE FABRE - CDI
Fonction : Non définie
Lieu : Non défini
Publiée : 11-10-2022
Date de début : Fri, 07 Oct 2022 13:55:08 Z
Date de fin : 07 11 2022
Niveau d’expérience pour ce poste :
Rémunération comprise entre € et € par
Poste nécessitant d’avoir un Permis B : Non
Référence interne : 80055&111022
Description de l'offre
Emploi : Projet/Directeur de programmes R&D
Contrat : CDI
Description du poste :
We are seeking a talented and highly motivated Biomarker Scientific Leader to join our oncology group and lead multidisciplinary biomarker enabling strategy within drug discovery programs from inception through early clinical testing. You will be responsible for providing the strategic leadership, scientific excellence, and cross-functional operational leadership to deliver high quality data packages supporting decision-making through preclinical and clinical phases. Biomarker concepts and data will inform proof of target hypothesis, mechanism of action, patient selection and clinical development path of novel therapeutics. More precisely: - Within the multidisciplinary project team, you are responsible to design and integrate the translational biomarker plan into the program strategy and execution - In tight collaboration with the project manager you drive the implementation and execution of the preclinical and clinical biomarker enabling strategy with plan, timelines, deliverables, budget, risk assessment and mitigation strategies - For the preclinical validation of the biomarker plan and its execution within clinical studies you collaborate with internal scientific and clinical experts across several functional areas (PK/PD, Toxicology, Histopathology, Data Science, Clinical Development) and manage external partners (central lab and testing vendors) to meet quality and timelines regarding clinical sample processing and data reporting according to specifications - You participate to CROs and testing vendors selection, define deliverables, quality, and success criteria - You develop SOPs and implements best practices - In collaboration with clinical and data management teams you participate to the elaboration of clinical documents and data management plan - You partake to sites trainings for biomarker sample management - With the support of biostatisticians, you analyze cross-functional biomarker data and interpret results - You are co-responsible with the project manager for internal and external resources, as well as for the generation and delivery of high-quality documentation for reviews and decision-making - You are pro-active and engaged in fostering external awareness on new trends, technologies, and opportunities - You participate to the scientific evaluation of external opportunities in R&D.

High flexibility about the location of this position. -          PhD or MD/PhD with post-doctoral experience in oncology / immuno-oncology and ideally 5 to 10 years of experience in drug discovery in one or several pharmaceutical industries / biotechs -          Successful track record of leading science and execution of biomarker strategy within drug discovery projects, from target validation to clinical development -          Experience with technologies to identify and characterize biomarkers such as RNaseq, flow cytometry, immunohistochemistry and omics analysis is a plus -          Is collaborative, inclusive with strong interpersonal and communication skills -          Is data driven, critical and objective in decision-making -          Strong leadership with experience leading projects in a multi-function matrix environment -          Monitors external landscapes and fosters evolution of internal directions and approaches -          Defines operational priorities and assigns ambitious and demanding objectives -          Drives a result-oriented culture to maximize quality of deliverables -          Excellent written and oral communication skills in English. French is a plus.
Lieu de travail : Toulouse (31)
Niveau d'études minimum requis : Niveau supérieur à Bac + 5
Langue / Niveau :
Anglais : 4 - Courant
Profil du candidat